Publications - PlantBioCoRe

^{31. Cytochrome p450 monooxygenases and uses thereof}

Thu-Thuy T Dang*, Trinh-don Nguyen, M Nguyen Tuan-Anh, Yuen Yee Leung (2024).

US Patent US20240084272A1

https://patents.google.com/patent/US20240084272A1/en

^{30. The Rauvolfia tetraphylla genome suggests multiple distinct biosynthetic routes for yohimbane monoterpene indole alkaloids}

Emily Amor Stander, Beata Lehka, Inês Carqueijeiro, Clément Cuello, Frederik G Hansson, Hans J Jansen, Thomas Dugé De Bernonville, Caroline Birer Williams, Valentin Vergès, Enzo Lezin, Marcus Daniel Brandbjerg Bohn Lorensen, Thu-Thuy Dang, Audrey Oudin, Arnaud Lanoue, Mickael Durand, Nathalie Giglioli-Guivarc’h, Christian Janfelt, Nicolas Papon, Ron P Dirks, Sarah Ellen O’connor, Michael Krogh Jensen, Sébastien Besseau, Vincent Courdavault (2023).

Communications Biology 6, 1197

https://doi.org/10.1038/s42003-023-05574-8

^{29. Integration of discovery and engineering in plant alkaloid research: Recent developments in elucidation, reconstruction, and repurposing biosynthetic pathways}

Van-Hung Bui, Carlos Eduardo Rodríguez-López, Thu-Thuy T. Dang* (2023).

Current Opinion in Plant Biology 74, 102379

https://doi.org/10.1016/j.pbi.2023.102379

^{28. A booster for vaccines from plants}

Helena H Chubatsu Nunes, Thu-Thuy T. Dang* (2023).

Science

https://doi.org/10.1126/science.adg8823

^{27. Directed Biosynthesis of Mitragynine Stereoisomers}

Carsten Schotte, Yindi Jiang, Dagny Grzech, Thu-Thuy T. Dang, Larissa C. Laforest, Francisco León, Marco Mottinelli, Satya Swathi Nadakuduti, Christopher R. McCurdy, and Sarah E. O’Connor* (2023).

Journal of the American Chemical Society

https://doi.org/10.1021/jacs.2c13644

^{26. Discovery of a cytochrome P450 enzyme catalyzing the formation of spirooxindole alkaloid scaffold}

TAM Nguyen, D Grzech, K Chung, Z Xia, TD Nguyen, TTT Dang* (2023).

Frontiers in Plant Science 14

https://doi.org/10.3389/fpls.2023.1125158

^{25. Leveraging synthetic biology and metabolic engineering to overcome obstacles in plant pathway elucidation}

BD Kwan, B Seligmann , TD Nguyen, J Franke , TTT Dang* (2023)

Current Opinion in Plant Biology, 2023, 71, 102330

https://doi.org/10.1016/j.pbi.2022.102330

^{24. Old path, new frontier.}

TD Nguyen, TTT Dang* (2022).

Nature Chemical Biology 18: 582–583.

https://doi.org/10.1038/s41589-022-01045-z

^{23. Chemoenzymatic strategies using biocatalysts from plants for the synthesis of valuable natural products.}

HHC Nunes, TD Nguyen, TTT Dang* (2022).

Current Opinion in Green and Sustainable Chemistry, 100627.

https://doi.org/10.1016/j.cogsc.2022.100627

^{22. Discovery and Characterization of Oxidative Enzymes Involved in Monoterpenoid Indole Alkaloid Biosynthesis.}

TAM Nguyen, M McConnachie, TD Nguyen, TTT Dang* (2022).

Methods in Molecular Biology 2505.

https://doi.org/10.1007/978-1-0716-2349-7_11

^{21. Discovering and harnessing oxidative enzymes for chemoenzymatic synthesis and diversification of anticancer camptothecin analogues.}

TAM Nguyen, TD Nguyen, YY Leung, M McConnachie, O Sannikov, Z Xia, TTT Dang* (2021).

Communications Chemistry 4:177.

https://doi.org/10.1038/s42004-021-00602-2

^{20. Editorial: Exploring and Engineering Plant Specialized Metabolism: Latest Advances and New Horizons}

Jakob Franke, Yang Zhang, Thu Thuy Thi Dang (2021)

Frontiers in Plant Science 12

https://doi.org/10.3389/fpls.2021.783465

^{19. Cytochrome P450 enzymes as key drivers of alkaloid chemical diversification in plants.}

TD Nguyen, TTT Dang* (2021).

Frontiers in Plant Science 12:682181.

https://doi.org/10.3389/fpls.2021.682181

^{18. Mitragyna speciosa (Kratom) Genome: a resource for data-mining potent pharmaceuticals that impact human health.}

Julia Brose, Kin H Lau, TTT Dang, John P Hamilton, Lívia do Vale Martins, Britta Hamberger, Bjoern Hamberger, Jiming Jiang, Sarah E O’Connor, C Robin Buell (2021).

Genes|Genomes|Genetics.

https://doi.org/10.1038/s42004-021-00602-2

^{17. Demystifying the momilactone pathway.}

TD Nguyen, TTT Dang* (2021).

Nature Chemical Biology 17: 126–128.

https://doi.org/10.1038/s41589-022-01045-z

^{16. Quantitation of Select Terpenes/Terpenoids and Nicotine Using Gas Chromatography–Mass Spectrometry with High-Temperature Headspace Sampling.}

Trinh-Don Nguyen, Seamus Riordan-Short, TTT Dang, Rob O’Brien, Matthew Noestheden (2020).

ACS Omega, 5:10:5565–5573

https://doi.org/10.3389/fpls.2021.682181

^{15. Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes.}

TTT Dang, Franke J, Carqueijeiro IST, Langley C, Courdavault V, O’Connor SE (2018).

Nature Chemical Biology 14:760.

https://doi.org/10.1038/s41589-018-0078-4

^{14. Two Tabersonine 6,7-Epoxidases Initiate Lochnericine-Derived Alkaloid Biosynthesis in Catharanthus roseus}

Inês Carqueijeiro, Stephanie Brown, Khoa Chung, Thu-Thuy Dang, Manish Walia, Sébastien Besseau, Thomas Dugé de Bernonville, Audrey Oudin, Arnaud Lanoue, Kevin Billet, Thibaut Munsch, Konstantinos Koudounas, Céline Melin, Charlotte Godon, Bienvenue Razafimandimby, Johan-Owen de Craene, Gaëlle Glévarec, Jillian Marc, Nathalie Giglioli-Guivarc’h, Marc Clastre, Benoit St-Pierre, Nicolas Papon, Rodrigo B Andrade, Sarah E O’Connor, Vincent Courdavault (2018)

Plant Physiology 177:1473-1486.

https://doi.org/10.1104/pp.18.00549

^{13. Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle}

Lorenzo Caputi, Jakob Franke, Scott C. Farrow, Khoa Chung, Richard M. E. Payne, Trinh-Don Nguyen, Thu-Thuy T. Dang,Inês Soares Teto Carqueijeiro, Konstantinos Koudounas,Thomas Dugé de Bernonville, Belinda Ameyaw, D. Marc Jones, Ivo Jose Curcino Vieira, Vincent Courdavault, Sarah E. O’Connor (2018).

Science 360(6394)

https://doi.org/10.1126/science.aat4100

^{12. A BAHD acyltransferase catalyzing 19- O -acetylation of tabersonine derivatives in roots of Catharanthus roseus enables combinatorial synthesis of monoterpene indole alkaloids}

Inês Carqueijeiro, Thomas Dugé de Bernonville, Arnaud Lanoue, Thu-Thuy Dang, Christiana N Teijaro, Christian Paetz, Kevin Billet, Angela Mosquera, Audrey Oudin, Sébastien Besseau, Nicolas Papon, Gaëlle Glévarec, Lucía Atehortùa, Marc Clastre, Nathalie Giglioli-Guivarc’h, Bernd Schneider, Benoit St-Pierre, Rodrigo B. Andrade, Sarah E. O’Connor, Vincent Courdavault (2018).

The Plant Journal 94(3)

https://doi.org/10.1111/tpj.13868

^{11. Discovery of a Short-Chain Dehydrogenase from Catharanthus roseus that Produces a New Monoterpene Indole Alkaloid}

AnnaK. Stavrinides, Evangelos C. Tatsis, Thu-Thuy Dang, Lorenzo Caputi, ClareE. M. Stevenson, DavidM. Lawson, Bernd Schneider, and SarahE.O’Connor (2018)

ChemBioChem 19(9): 940–948

https://doi.org/10.1002/cbic.201700621

^{10. A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate}

Evangelos C. Tatsis, Inês Carqueijeiro, Thomas Dugé de Bernonville, Jakob Franke, Thu-Thuy T. Dang, Audrey Oudin, Arnaud Lanoue, Florent Lafontaine, Anna K. Stavrinides, Marc Clastre, Vincent Courdavault & Sarah E. O’Connor (2017)

Nature Communications 8(1)

https://doi.org/10.1038/s41467-017-00154-x

^{9. Dual catalytic activity of a cytochrome P450 controls bifurcation at a metabolic branch point of alkaloid biosynthesis in Rauwolfia serpentina.}

TTT Dang, Franke J, Tatsis E, O’Connor SE (2017).

Angewandte Chemie International Edition 56:9440.

https://doi.org/10.1002/anie.201705010

^{8. Noscapine comes of age}

Chen X, TTT Dang, Facchini PJ (2015).

Phytochemistry 111

https://doi.org/10.1016/j.phytochem.2014.09.008

^{7. Acetylation serves as a protective group in noscapine biosynthesis in opium poppy.}

TTT Dang, Chen X, Facchini PJ (2015).

Nature Chemical Biology 11:104.

https://doi.org/10.1038/nchembio.1717

^{6. CYP82Y1 is N-methylcanadine 1-hydroxylase, a key noscapine biosynthetic enzyme in opium poppy.}

TTT Dang, Facchini PJ (2014).

Journal of Biological Chemistry 289:2013.

https://doi.org/10.1074/jbc.M113.505099

^{5. Cloning and characterization of canadine synthase involved in noscapine biosynthesis in opium poppy}

TTT Dang, Facchini PJ (2013).

FEBS Letters 588(1)

https://doi.org/10.1016/j.febslet.2013.11.037

^{4. Biochemical genomics for gene discovery in benzylisoquinoline alkaloid biosynthesis in opium poppy and related species.}

TTT Dang, Onoyovwi AK, Farrow SC, Facchini PJ (2012).

Methods in Enzymology 515:231.

https://doi.org/10.1016/B978-0-12-394290-6.00011-2

^{3. Characterization of three O-methyltransferases involved in noscapine biosynthesis in opium poppy.}

TTT Dang, Facchini PJ (2012).

Plant Physiology 159:618

https://doi.org/10.1104/pp.112.194886

^{2. Differences in cellular structure regulate stem elongation of alpine and prairie ecotypes of Stellaria longipes grown under two contrasting temperature regimes.}

TTT Dang, Yeung EC, Chinnappa CC (2009).

Botany 87:1167.

https://doi.org/10.1139/B09-077

^{1. The reproductive biology of Stellaria longipes Goldie (Caryophyllaceae) in North America}

TTT Dang, Chinnappa CC (2007).

Flora – Morphology Distribution Functional Ecology of Plants 202(5):403-407

https://doi.org/10.1016/j.flora.2006.08.005